[Contributor's comment]:
[Keywords]:
Too much should be controlled, non-self / self-identifying ability, and artificial thymus gland to solve them all at once
[Subject]:
[Important Recommendations]How can we solve both "immune disorders (allergic diseases)" and "metabolic disorders" in one fell swoop?
[Text of the post]:
"Foxp3 gene" → "T-leg" → "reproduction and metabolism" is realized → produced by "thymus gland" →?
"T-leg" is not only controlling "self/nonself" ON/OFF, but also controlling quantitatively from 0.0 to 1.0?
Could metabolic abnormalities be "T-leg" runaway, in which the "T-leg" has lost quantitative control?
If "artificial thymus" is used to "re-educate" T-legs and "killer T cells" (i.e., strengthen their discriminatory ability).
If T-legs and killer T cells are re-educated by an artificial thymus, both immunological diseases (allergic diseases) and metabolic disorders may be solved at once.
"NR4A gene" → "Killer T cells" excessively attack "aged cells" → "Killer T" is exhausted and its attack is suppressed
→ Might it be possible to suppress the "runaway immunity (multi-organ failure, etc.)" of "Killer T"?
"Naive T" → Produced by the thymus gland, which disappears in adolescence.
Memory-type T" is generated in adulthood and after.
Create an optimized "artificial thymus" using "cell differentiation technology" such as IPS cell technology?
